The Evolution of Antimycobacterial Agents from Non-Antibiotics
نویسندگان
چکیده
The antimicrobial action of a number of non-antibiotic drugs has been demonstrated in recent years, for example the antimycobacterial activity associated with the phenothiazine neuroleptic class. However, as with other classes of non-antibiotics, such activity may be traced back to common precursor structures such as the phenothiazinium dye, methylene blue. While the rising tide of antimicrobial drug resistance has nullified the effects of many conventional agents, several of the original lead compounds and their non-antibiotic derivatives may have a new part to play in the chemotherapy of infectious disease, particularly in the management of
منابع مشابه
3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کامل3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کاملSynthesis of new 1,3-thiazoline-2-thiones as potential antimycobacterial agents
As a continuation of our efforts in developing new antimycobacterial agents, a series of new 1,3-thiazolidine-2-thione derivatives were synthesized. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. The analysis of theoretical toxicity risks,drug-likeness and drug-score for these series using Osiris program showed acceptable results.
متن کاملIn-silico Metabolome Target Analysis Towards PanC-based Antimycobacterial Agent Discovery
Mycobacterium tuberculosis, the main cause of tuberculosis (TB), has still remained a global health crisis especially in developing countries. Tuberculosis treatment is a laborious and lengthy process with high risk of non compliance, cytotoxicity adverse events and drug resistance in patient. Recently, there has been an alarming rise of drug resistant in TB. In this regard, it is an unmet need...
متن کاملConstruction of a bioluminescent mycobacterium and its use for assay of antimycobacterial agents.
To show, as a model system, that mycobacteria can express heterologous luciferase genes and that bioluminescence can be a rapid method of measuring antimycobacterial activity, a bioluminescent form of Mycobacterium smegmatis was made by transformation with a Mycobacterium-Escherichia coli shuttle vector containing the luxAB genes from Vibrio harveyi. The antimycobacterial effects of antibiotics...
متن کامل